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Luspatercept for Transfusion-Dependent β-Thalassemia

Brady L. Stein, MD, MHS reviewing Cappellini MD et al. N Engl J Med 2020 Mar 26

Luspatercept reduced transfusion burden compared with placebo.


Detecting Metastatic Prostate Cancer with Prostate-Specific Membrane Antigen PET-CT

Robert Dreicer, MD, MS, MACP, FASCO reviewing Hofman MS et al. Lancet 2020 Mar 22, Moore C. Lancet 2020 Mar 22

PSMA PET-CT had greater sensitivity and specificity than conventional imaging for detecting pelvic nodal or distant metastases in men with high-risk prostate cancer.


Molecularly Matched Treatment for Pancreatic Cancer

David H. Ilson, MD, PhD reviewing Pishvaian MJ et al. Lancet Oncol 2020 Mar 2

Overall survival was significantly improved with matched versus unmatched therapy.


New Clinical Trial Data in Patients with Upper Tract Urothelial Cancer

Robert Dreicer, MD, MS, MACP, FASCO reviewing Birtle A et al. Lancet 2020 Mar 5, Crabb SJ. Lancet 2020 Mar 5

Adjuvant platinum-based chemotherapy conferred significant reductions in disease-free survival.


Pharmacogenomics of Tamoxifen: Can Therapeutic Outcomes Be Tailor Made?

William J. Gradishar, MD reviewing He W et al. J Clin Oncol 2020 Feb 20, Tamura K et al. J Clin Oncol 2020 Feb 20, Hayes DF and Rae JM. J Clin Oncol 2020 Feb 20

High-level supporting evidence for CYP2D6 genotype-guided tamoxifen dosing is still lacking.


Outcomes of Iron Chelation for Lower-Risk Myelodysplastic Syndrome

Brady L. Stein, MD, MHS reviewing Hoeks M et al. Haematologica 2020 Mar

Chelation therapy is associated with improvements in overall survival and transfusion intensity in patients with lower-risk MDS.


MRI-Targeted and Systematic Biopsy for Prostate Cancer Diagnosis

Robert Dreicer, MD, MS, MACP, FASCO reviewing Ahdoot M et al. N Engl J Med 2020 Mar 5

More cancers were diagnosed by using both techniques than by using either one alone.


Clinical Presentations of Patients with Paroxysmal Nocturnal Hemoglobinuria Clones

Brady L. Stein, MD, MHS reviewing Richards SJ et al. Br J Haematol 2020 Feb 27

Among patients with PNH clones, 66% had cytopenias and 29% had hemolytic features.


EUS-Guided Injection of a Modified Adenovirus for Pancreatic Cancer

Douglas G. Adler, MD, FACG, AGAF, FASGE reviewing Lee J-C et al. Gastrointest Endosc 2020 Feb 18

This novel approach appeared to be safe and potentially efficacious, in a small phase I trial.


Is ERCC1 Expression a Useful Biomarker in Esophagogastric Cancer?

David H. Ilson, MD, PhD reviewing Iqbal S et al. J Clin Oncol 2020 Feb 10

High ERCC1 status provided no predictive value for treatment outcome.


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