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Chemotherapy for Isolated Locoregional Recurrence of Breast Cancer

Henry Mark Kuerer, MD, PhD, FACS reviewing Wapnir IL et al. J Clin Oncol 2018 Apr 10

Long-term results confirm a benefit for ER-negative but not ER-positive patients.


Neoadjuvant Nivolumab for Resectable Lung Cancer

Anne S. Tsao, MD reviewing Forde PM et al. N Engl J Med 2018 Apr 16

A major pathological response was seen in 45% of patients.


First-Line Nivolumab plus Ipilimumab for Advanced Non–Small-Cell Lung Cancer

Anne S. Tsao, MD reviewing Hellmann MD et al. N Engl J Med 2018 Apr 16

Progression-free survival was improved versus chemotherapy for patients with high tumor mutation burden.


Immune-Related Adverse Events for Anti-PD-1 Agents

Anne S. Tsao, MD reviewing Baxi S et al. BMJ 2018 Mar 14

Checkpoint inhibitors for various cancers increased the risk for colitis, pneumonitis, hypothyroidism, hypophysitis, and rash compared with standard-of-care chemotherapies.


Thromboembolism in Patients with Acute Lymphoblastic Leukemia

David Green, MD, PhD reviewing Rank CU et al. Blood 2018 Apr 16

The 2.5-year cumulative incidence was 7.9% in patients aged 1 to 45 years; risk was greater in patients 10 years of age and older.


Incorporating Mammographic Density in a Breast Cancer Risk Assessment Tool

Laila Samiian, MD, FACS reviewing Brentnall AR et al. JAMA Oncol 2018 Apr 5

With or without breast density, the Tyrer-Cuzick model was equally effective in identifying high-risk women.


Risk for Contralateral Breast Cancer — A Family Affair?

Andrew M. Kaunitz, MD reviewing Reiner AS et al. J Clin Oncol 2018 Apr 5

A large international study shows family history can confer excess risk for contralateral breast cancer, even without known deleterious mutations.


Is Pregnancy Safe After Breast Cancer?

William J. Gradishar, MD reviewing Lambertini M et al. J Natl Cancer Inst 2018 Apr 1

Long-term outcomes were similar between pregnant and nonpregnant survivors.


Neutrophil Extracellular Traps Predict Venous Thromboembolism

David Green, MD, PhD reviewing Mauracher LM et al. J Thromb Haemost 2018 Mar

Histone H3, a NETS biomarker, is an independent predictor of VTE in cancer patients.


Postoperative Carcinoembryonic Antigen Levels Are Prognostic in Colon Cancer

David H. Ilson, MD, PhD reviewing Konishi T et al. JAMA Oncol 2018 Mar 1

Relapse-free survival was inferior in stage III patients with persistent postoperative CEA elevation.


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Editorial Member Board Empfehlungen

PD Dr. med. Katja Zirlik

Hämatologie und internistische Onkologie
Tumorzentrum ZeTuP Chur

E-Mail: E-Mail anzeigen

Liebe Kolleginnen und Kollegen!

Beim nicht kleinzelligen Lungenkarzinom (NSCLC) ist die Immuntherapie bereits in allen Therapielinien zugelassen. Die immunhistochemische Bestimmung der PD-L1-Expression auf den Tumorzellen ist derzeit der am besten validierte prädiktive Biomarker für die Therapie mit Checkpoint-Inhibitoren. Die vorliegende Studie untersuchte bei 848 Patienten mit NSCLC, ob die Mutationslast («tumor mutational burden», TMB), mittels «next-generation sequencing» (NGS) bestimmt, einen weiteren Marker darstellt, der die Wirksamkeit der Immuntherapie vorhersagen kann. Eine höhere Mutationslast war assoziiert mit einer Verbesserung im Hinblick auf die Ansprechrate sowie die Ansprechdauer. NSCLC-Patienten mit einer hohen Mutationslast profitieren demnach mehr von einer Immuntherapie.

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First-Line Lenvatinib vs. Sorafenib for Unresectable Hepatocellular Carcinoma

David H. Ilson, MD, PhD reviewing Kudo M et al. Lancet 2018 Feb 9, Reig M and Bruix J. Lancet 2018 Feb 9

Overall survival was noninferior and progression-free survival and response were superior with lenvatinib.


Apalutamide for Castration-Resistant PSA-Only Prostate Cancer

Robert Dreicer, MD, MS, FACP, FASCO reviewing Smith MR et al. N Engl J Med 2018 Feb 8

Metastasis-free survival was significantly longer with apalutamide than with placebo.


Second-Line Olaparib for Gastric Cancer

David H. Ilson, MD, PhD reviewing Bang Y-J et al. Lancet Oncol 2017 Dec

Contrary to prior findings, adding olaparib to paclitaxel failed to improve survival in patients with disease progression following chemotherapy.


Predicting Response to Immunotherapy in Non–Small-Cell Lung Cancer

Anne S. Tsao, MD reviewing Rizvi H et al. J Clin Oncol 2018 Jan 16

Assessment of tumor mutation burden using targeted next-generation sequencing may be predictive of benefit from PD-1 and PD-L1 inhibitors.


Prolonged Adjuvant Aromatase Inhibitor Treatment for Early Breast Cancer

William J. Gradishar, MD reviewing Blok EJ et al. J Natl Cancer Inst 2018 Jan 1, Goldvaser H et al. J Natl Cancer Inst 2018 Jan 1, Pohlmann PR and Isaacs C. J Natl Cancer Inst 2018 Jan 1

Outcomes were not superior with 5 versus 2.5 years of extended letrozole therapy.


Prognosis of Monoclonal Gammopathy of Undetermined Significance

David Green, MD, PhD reviewing Kyle RA et al. N Engl J Med 2018 Jan 18

Overall survival was significantly shorter among MGUS patients than among a matched control population in a long-term follow-up study.


Prognosis for BRCA-Mutated Breast Cancer

William J. Gradishar, MD reviewing Copson ER et al. Lancet Oncol 2018 Jan 11

Survival is similar between BRCA mutation carriers versus those with sporadic disease.


Electrical Field Therapy for Glioblastoma

Roy E. Strowd, MD reviewing Stupp R et al. JAMA 2017 Dec 19

Adding tumor-treating electrical-field therapy to maintenance temozolomide chemotherapy significantly improved survival in patients with newly diagnosed glioblastoma.


Atezolizumab for Advanced Urothelial Cancer

Robert Dreicer, MD, MS, FACP, FASCO reviewing Powles T et al. Lancet 2017 Dec 18, Massari F and Di Nunno V. Lancet 2017 Dec 18

Overall survival was not improved with the PD-L1 inhibitor atezolizumab versus chemotherapy in patients with highest PD-L1 expression.


Pembrolizumab for Cisplatin-Ineligible Patients with Advanced Urothelial Cancer

Robert Dreicer, MD, MS, FACP, FASCO reviewing Balar AV et al. Lancet Oncol 2017 Sep 26

First-line therapy demonstrated antitumor activity in a phase II study.