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Best of ASCO

Wichtige Studien im Überblick

<p class="article-intro">In den Oral Abstract Sessions werden von der ASCO die relevantesten der eingereichten Studien ausgewählt. Viele relevante und interessante Studien schaffen es nicht in die oralen Sessions und werden als Poster präsentiert. Hier finden Sie einen Überblick über einige der wichtigsten Studien aus der Postersession.</p> <hr /> <p class="article-content"><table border="1" width="100 % " cellspacing="0"><colgroup><col width="10 % " /> <col width="17 % " /> <col width="60 % " /> <col width="13 % " /> </colgroup> <tbody> <tr> <td class="xl65" style="padding: 5px;" width="100" height="25"> <h4 style="padding: 5px; text-align: center;">Abstr. #</h4> </td> <td class="xl65" style="padding: 5px;" width="143"> <h4 style="padding: 5px; text-align: center;">Erstautor</h4> </td> <td class="xl65" style="padding: 5px;" width="528"> <h4>Titel</h4> </td> <td class="xl65" style="padding: 5px; text-align: center;" width="88"> <h4>URL</h4> </td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>Mammakarzinom</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">500</td> <td style="padding: 5px; text-align: center;">Hurvitz SA</td> <td class="xl67" style="padding: 5px;">Neoadjuvant trastuzumab (H), pertuzumab (P), and chemotherapy versus trastuzumab emtansine (T-DM1) and P in human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC): Final outcome results from the phase III KRISTINE study</td> <td class="xl70" style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.500" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">504</td> <td style="padding: 5px; text-align: center;">Del Mastro L</td> <td class="xl67" style="padding: 5px;">Benefit from letrozole as extended adjuvant therapy after sequential endocrine therapy: A randomized, phase III study of Gruppo Italiano Mammella (GIM)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.504" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">508</td> <td style="padding: 5px; text-align: center;">Ganz PA</td> <td class="xl67" style="padding: 5px;">Patient-reported outcomes (PROs) in NRG oncology/NSABP B-39/RTOG 0413: A randomized phase III study of conventional whole breast irradiation (WBI) versus&nbsp;partial breast irradiation (PBI) in stage 0, I, or II breast cancer</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.508" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">1000</td> <td style="padding: 5px; text-align: center;">Rugo HS</td> <td class="xl67" style="padding: 5px;">SOPHIA primary analysis: A phase 3 (P3) study of margetuximab (M) + chemotherapy (C) versus trastuzumab (T) + C in patients (pts) with HER2+ metastatic (met) breast cancer (MBC) after prior anti-HER2 therapies (Tx)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.1000" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">1001</td> <td style="padding: 5px; text-align: center;">Jiang Z</td> <td class="xl67" style="padding: 5px;">Pyrotinib combined with capecitabine in women with HER2+ metastatic breast cancer previously treated with trastuzumab and taxanes: A randomized phase III study</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.1001" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">1002</td> <td style="padding: 5px; text-align: center;">Saura C</td> <td class="xl67" style="padding: 5px;">Neratinib + capecitabine versus lapatinib + capecitabine in patients with HER2+ metastatic breast cancer previously treated with &ge; 2 HER2-directed regimens: Findings from the multinational, randomized, phase III NALA trial</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.1002" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">1003</td> <td style="padding: 5px; text-align: center;">Schmid P</td> <td class="xl67" style="padding: 5px;">IMpassion130: updated overall survival (OS) from a global, randomized, double-blind, placebo-controlled, Phase III study of atezolizumab (atezo) +&nbsp;nab-paclitaxel (nP) in previously untreated locally advanced or metastatic triple-negative breast cancer (mTNBC)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.1003" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">LBA1008</td> <td style="padding: 5px; text-align: center;">Hurvitz SA</td> <td class="xl68" style="padding: 5px;">Phase III MONALEESA-7 trial of premenopausal patients with HR+/HER2&minus; advanced breast cancer (ABC) treated with endocrine therapy &plusmn; ribociclib: Overall survival (OS) results</td> <td style="padding: 5px; text-align: center;"><a href="https://abstracts.asco.org/239/AbstView_239_272829.html" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>Gyn&auml;kologische Tumoren (au&szlig;er Mammakarzinom)</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">5500</td> <td style="padding: 5px; text-align: center;">Powell MA</td> <td class="xl67" style="padding: 5px;">A randomized phase 3 trial of paclitaxel (P) plus carboplatin (C) versus paclitaxel plus ifosfamide (I) in chemotherapy-naive patients with stage I-IV, persistent or recurrent carcinosarcoma of the uterus or ovary: An NRG Oncology trial</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5500" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">5505</td> <td style="padding: 5px; text-align: center;">Mirza MR</td> <td class="xl67" style="padding: 5px;">Combination of niraparib and bevacizumab versus niraparib alone as treatment of recurrent platinum-sensitive ovarian cancer: A randomized controlled chemotherapy-free study&mdash;NSGO-AVANOVA2/ENGOT-OV24</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5505" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">5506</td> <td style="padding: 5px; text-align: center;">Penson RT</td> <td class="xl67" style="padding: 5px;">Olaparib monotherapy versus (vs) chemotherapy for germline BRCA-mutated (gBRCAm) platinum-sensitive relapsed ovarian cancer (PSR OC) patients (pts): Phase III SOLO3 trial</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5506" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">5507</td> <td style="padding: 5px; text-align: center;">Vanderstichele A</td> <td class="xl67" style="padding: 5px;">Randomized phase II CLIO study on olaparib monotherapy versus chemotherapy in platinum-resistant ovarian cancer</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5507" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">5508</td> <td style="padding: 5px; text-align: center;">Falandry C</td> <td class="xl67" style="padding: 5px;">EWOC-1: A randomized trial to evaluate the feasibility of three different first-line chemotherapy regimens for vulnerable elderly women with ovarian cancer (OC): A GCIG-ENGOT-GINECO study</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5508" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>Prostatakarzinom</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">5000</td> <td style="padding: 5px; text-align: center;">Fizazi K</td> <td class="xl67" style="padding: 5px;">Impact of darolutamide (DARO) on pain and quality of life (QoL) in patients (Pts) with nonmetastatic castrate-resistant prostate cancer (nmCRPC)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5000" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">5001</td> <td style="padding: 5px; text-align: center;">Carrie C</td> <td class="xl67" style="padding: 5px;">Interest of short hormonotherapy (HT) associated with radiotherapy (RT) as salvage treatment for metastatic free survival (MFS) after radical prostatectomy (RP): Update at 9 years of the GETUG-AFU 16 phase III randomized trial (NCT00423475)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5001" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">5006</td> <td style="padding: 5px; text-align: center;">Chi KN</td> <td class="xl67" style="padding: 5px;">First results from TITAN: A phase III double-blind, randomized study of apalutamide (APA) versus placebo (PBO) in patients (pts) with metastatic castration-sensitive prostate cancer (mCSPC) receiving androgen deprivation therapy (ADT)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5006" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">5007</td> <td style="padding: 5px; text-align: center;">Tombal BF</td> <td class="xl67" style="padding: 5px;">Decreased fracture rate by mandating bone-protecting agents in the EORTC 1333/PEACE III trial comparing enzalutamide and Ra223 versus enzalutamide alone: An interim safety analysis</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5007" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">5008</td> <td style="padding: 5px; text-align: center;">Morris MJ</td> <td class="xl67" style="padding: 5px;">Alliance A031201: A phase III trial of enzalutamide (ENZ) versus enzalutamide, abiraterone, and prednisone (ENZ/AAP) for metastatic castration resistant prostate cancer (mCRPC)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5008" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>Urologische Tumoren (au&szlig;er Prostatakarzinom)</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4500</td> <td style="padding: 5px; text-align: center;">Rini BI</td> <td class="xl67" style="padding: 5px;">Pembrolizumab (pembro) plus axitinib (axi) versus sunitinib as first-line therapy for metastatic renal cell carcinoma (mRCC): Outcomes in the combined IMDC intermediate/poor risk and sarcomatoid subgroups of the phase 3 KEYNOTE-426 study</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4500" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4501</td> <td style="padding: 5px; text-align: center;">Gao J</td> <td class="xl67" style="padding: 5px;">A pilot randomized study evaluating nivolumab (nivo) or nivo + bevacizumab (bev) or nivo + ipilimumab (ipi) in patients with metastatic renal cell carcinoma (MRCC) eligible for cytoreductive nephrectomy, metastasectomy or post-treatment biopsy (Bx)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4501" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4502</td> <td style="padding: 5px; text-align: center;">Appleman LJ</td> <td class="xl67" style="padding: 5px;">Randomized, double-blind phase III study of pazopanib versus placebo in patients with metastatic renal cell carcinoma who have no evidence of disease following metastasectomy: A trial of the ECOG-ACRIN cancer research group (E2810)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4502" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4503</td> <td style="padding: 5px; text-align: center;">Rosenberg JE</td> <td class="xl67" style="padding: 5px;">CALGB 90601 (Alliance): Randomized, double-blind, placebo-controlled phase III trial comparing gemcitabine and cisplatin with bevacizumab or placebo in patients with metastatic urothelial carcinoma</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4503" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4507</td> <td style="padding: 5px; text-align: center;">Zaghloul MS</td> <td class="xl67" style="padding: 5px;">Randomized trial of adjuvant chemotherapy versus adjuvant radiation therapy for locally advanced bladder cancer after radical cystectomy</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4507" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4508</td> <td style="padding: 5px; text-align: center;">Mejean A</td> <td class="xl67" style="padding: 5px;">Cytoreductive nephrectomy (CN) in metastatic renal cancer (mRCC): Update on Carmena trial with focus on intermediate IMDC-risk population</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4508" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>Kolorektalkarzinom</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">3500</td> <td style="padding: 5px; text-align: center;">Sougklakos I</td> <td class="xl67" style="padding: 5px;">Three versus six months adjuvant FOLFOX or CAPOX for high risk stage II and stage III colon cancer patients: The efficacy results of Hellenic Oncology Research Group (HORG) participation to the International Duration Evaluation of Adjuvant chemotherapy (IDEA) project</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.3500" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">3501</td> <td style="padding: 5px; text-align: center;">Iveson T</td> <td class="xl67" style="padding: 5px;">Prospective pooled analysis of four randomized trials investigating duration of adjuvant (adj) oxaliplatin-based therapy (3 vs 6 months {m}) for patients (pts) with high-risk stage II colorectal cancer (CC)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.3501" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">3502</td> <td style="padding: 5px; text-align: center;">Shi Q</td> <td class="xl67" style="padding: 5px;">Re-evaluating disease-free survival (DFS) as an endpoint versus overall survival (OS) in adjuvant colon cancer (CC) trials with chemotherapy +/- biologics: An updated surrogacy analysis based on 18,886 patients (pts) from the Accent database</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.3502" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">3507</td> <td style="padding: 5px; text-align: center;">Sastre J</td> <td class="xl67" style="padding: 5px;">Randomized phase III study comparing FOLFOX + bevacizumab versus folfoxiri + bevacizumab (BEV) as 1st line treatment in patients with metastatic colorectal cancer (mCRC) with &ge;3 baseline circulating tumor cells (bCTCs)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.3507" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">3508</td> <td style="padding: 5px; text-align: center;">Cremolini C</td> <td class="xl67" style="padding: 5px;">Updated results of TRIBE2, a phase III, randomized strategy study by GONO in the first- and second-line treatment of unresectable mCRC</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.3508" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>Gastrointestinale Tumoren (au&szlig;er Kolorektalkarzinom)</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4000</td> <td style="padding: 5px; text-align: center;">Tempero MA</td> <td class="xl67" style="padding: 5px;">APACT: phase III, multicenter, international, open-label, randomized trial of adjuvant&nbsp;nab-paclitaxel plus gemcitabine (nab-P/G) vs gemcitabine (G) for surgically resected pancreatic adenocarcinoma</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4000" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4001</td> <td style="padding: 5px; text-align: center;">Park SH</td> <td class="xl67" style="padding: 5px;">ARTIST 2: Interim results of a phase III trial involving adjuvant chemotherapy and/or chemoradiotherapy after D2-gastrectomy in stage II/III gastric cancer (GC)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4001" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4003</td> <td style="padding: 5px; text-align: center;">Lamarca A</td> <td class="xl67" style="padding: 5px;">ABC-06 | A randomised phase III, multi-centre, open-label study of Active Symptom Control (ASC) alone or ASC with oxaliplatin / 5-FU chemotherapy (ASC+mFOLFOX) for patients (pts) with locally advanced / metastatic biliary tract cancers (ABC) previously-treated with cisplatin/gemcitabine (CisGem) chemotherapy</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4003" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4004</td> <td style="padding: 5px; text-align: center;">Finn RS</td> <td class="xl67" style="padding: 5px;">Results of KEYNOTE-240: phase 3 study of pembrolizumab (Pembro) vs best supportive care (BSC) for second line therapy in advanced hepatocellular carcinoma (HCC)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4004" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4005</td> <td style="padding: 5px; text-align: center;">Bergsland EK</td> <td class="xl67" style="padding: 5px;">Prospective randomized phase II trial of pazopanib versus placebo in patients with progressive carcinoid tumors (CARC)&nbsp;(Alliance A021202)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4005" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">4006</td> <td style="padding: 5px; text-align: center;">Hall PS</td> <td class="xl67" style="padding: 5px;">Optimizing chemotherapy for frail and elderly patients (pts) with advanced gastroesophageal cancer (aGOAC): The GO2 phase III trial</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.4006" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">LBA4007</td> <td style="padding: 5px; text-align: center;">Tabernero J</td> <td class="xl68" style="padding: 5px;">Pembrolizumab with or without chemotherapy versus chemotherapy for advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: The phase III KEYNOTE-062 study</td> <td style="padding: 5px; text-align: center;"><a href="https://abstracts.asco.org/239/AbstView_239_251955.html" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>Lungenkarzinom</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">8501</td> <td style="padding: 5px; text-align: center;">Kenmotsu H</td> <td class="xl67" style="padding: 5px;">Randomized phase III study of pemetrexed/cisplatin (Pem/Cis) versus vinorelbine /cisplatin (Vnr/Cis) for completely resected stage II-IIIA non-squamous non-small-cell lung cancer (Ns-NSCLC): The JIPANG study</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.8501" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">9000</td> <td style="padding: 5px; text-align: center;">Nakagawa K</td> <td class="xl67" style="padding: 5px;">RELAY: A multinational, double-blind, randomized Phase 3 study of erlotinib (ERL) in combination with ramucirumab (RAM) or placebo (PL) in previously untreated patients with epidermal growth factor receptor mutation-positive (EGFRm) metastatic non-small cell lung cancer (NSCLC)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.9000" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">9001</td> <td style="padding: 5px; text-align: center;">Noronha V</td> <td class="xl67" style="padding: 5px;">Phase III randomized trial comparing gefitinib to gefitinib with pemetrexed-carboplatin chemotherapy in patients with advanced untreated EGFR mutant non-small cell lung cancer (gef vs gef+C)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.9001" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">9002</td> <td style="padding: 5px; text-align: center;">Ramalingam SS</td> <td class="xl67" style="padding: 5px;">ECOG-ACRIN 5508: Pemetrexed, bevacizumab or the combination as maintenance therapy for advanced non-squamous NSCLC</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.9002" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">9003</td> <td style="padding: 5px; text-align: center;">Seto T</td> <td class="xl67" style="padding: 5px;">A randomized phase III study of continuous maintenance bevacizumab with or without pemetrexed after induction therapy with carboplatin (Car), pemetrexed (Pem), and bevacizumab (Bev) for advanced non-squamous non-small cell lung cancer (nSQ-NSCLC) without sensitizing EGFR mutations: The COMPASS study (WJOG5610L)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.9003" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>Hals-Kopf-Tumoren</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">6000</td> <td style="padding: 5px; text-align: center;">Rischin D</td> <td class="xl67" style="padding: 5px;">Protocol-specified final analysis of the phase 3 KEYNOTE-048 trial of pembrolizumab (pembro) as first-line therapy for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.6000" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">6002</td> <td style="padding: 5px; text-align: center;">Guigay J</td> <td class="xl67" style="padding: 5px;">TPExtreme randomized trial: TPEx versus Extreme regimen in 1st line recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.6002" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">6003</td> <td style="padding: 5px; text-align: center;">Ma J</td> <td class="xl67" style="padding: 5px;">Gemcitabine and cisplatin (GP) induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) versus CCRT alone in locoregionally advanced nasopharyngeal carcinoma (NPC): A phase 3, multicenter, randomized controlled trial</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.6003" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">6004</td> <td style="padding: 5px; text-align: center;">Chen MY</td> <td class="xl67" style="padding: 5px;">Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: Long-term results of a phase 3 multicenter randomized controlled trial</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.6004" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>Melanom</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">9500</td> <td style="padding: 5px; text-align: center;">Fogarty G</td> <td class="xl67" style="padding: 5px;">Phase 3 international trial of adjuvant whole brain radiotherapy (WBRT) or observation (Obs) following local treatment of 1-3 melanoma brain metastases (MBMs)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.9500" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">9504</td> <td style="padding: 5px; text-align: center;">Tarhini AA</td> <td class="xl67" style="padding: 5px;">United States Intergroup E1609: A phase III randomized study of adjuvant ipilimumab (3 or 10 mg/kg) versus high-dose interferon-&alpha;2b for resected high-risk melanoma</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.9504" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>Sarkome</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">11000</td> <td style="padding: 5px; text-align: center;">Gronchi A</td> <td class="xl67" style="padding: 5px;">Neoadjuvant chemotherapy in high-risk soft tissue sarcomas: Final results of a randomized clinical trial from the Italian Sarcoma Group, the Spanish Sarcoma Group (GEIS), the French Sarcoma Group (FSG), and the Polish Sarcoma Group (PSG)</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.11000" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">11001</td> <td style="padding: 5px; text-align: center;">Bonvalot S</td> <td class="xl67" style="padding: 5px;">STRASS (EORTC 62092): A phase III randomized study of preoperative radiotherapy plus surgery versus surgery alone for patients with retroperitoneal sarcoma</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.11001" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">11002</td> <td style="padding: 5px; text-align: center;">Weiss AR</td> <td class="xl67" style="padding: 5px;">Preoperative chemoradiation +/- pazopanib in non-rhabdomyosarcoma soft tissue sarcoma (NRSTS): A report from Children's Oncology Group (COG) and NRG Oncology</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.11002" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl69" style="padding: 5px;" colspan="4" height="20"> <h4>ZNS-Tumore</h4> </td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">2000</td> <td style="padding: 5px; text-align: center;">Van Den Bent MJ</td> <td class="xl67" style="padding: 5px;">Second interim and first molecular analysis of the EORTC randomized phase III intergroup CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p/19q codeletion</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.2000" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">2001</td> <td style="padding: 5px; text-align: center;">Balana C</td> <td class="xl67" style="padding: 5px;">Randomized phase IIb clinical trial of continuation or non-continuation with six cycles of temozolomide after the first six cycles of standard first-line treatment in patients with glioblastoma: A Spanish research group in neuro-oncology (GEINO) trial</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.2001" target="_parent">weiterlesen</a></td> </tr> <tr> <td class="xl66" style="padding: 5px; text-align: center;" height="20">2002</td> <td style="padding: 5px; text-align: center;">Bell EH</td> <td class="xl67" style="padding: 5px;">Updated predictive analysis of the WHO-defined molecular subgroups of low-grade gliomas within the high-risk treatment arms of NRG Oncology/RTOG 9802</td> <td style="padding: 5px; text-align: center;"><a href="https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.2002" target="_parent">weiterlesen</a></td> </tr> </tbody> </table></p>
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