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Shorter-Duration Adjuvant Therapy for High-Risk Stage II Colorectal Cancer

David H. Ilson, MD, PhD reviewing Petrelli F et al. JAMA Oncol 2020 Feb 13

Five-year relapse-free survival was noninferior with 3 versus 6 months of capecitabine and oxaliplatin.

Clinical Significance of Neutropenia Identified in Primary Care Offices

Brady L. Stein, MD, MHS reviewing Palmblad J et al. Am J Hematol 2020 Feb 13

Severity of neutropenia and concurrent presence of other cytopenias increase the likelihood of a viral infection or hematological malignancy.

Ramucirumab plus Docetaxel After Platinum-Based Therapy for Advanced Urothelial Cancer

Robert Dreicer, MD, MS, MACP, FASCO reviewing Petrylak DP et al. Lancet Oncol 2020 Jan

Progression-free survival remained improved versus docetaxel alone during extended follow-up.

Intravenous Iron and Hypophosphatemia in Patients with Iron Deficiency Anemia

Brady L. Stein, MD, MHS reviewing Wolf M et al. JAMA 2020 Feb 4

Rates of hypophosphatemia were higher with ferric carboxymaltose than with ferric derisomaltose.

The 2020 Gastrointestinal Cancers Symposium

David H. Ilson, MD, PhD

Highlights of the latest gastrointestinal cancer trials

Breast-Implant–Associated Anaplastic Large Cell Lymphoma

Henry Mark Kuerer, MD, PhD, FACS reviewing Jaffe ES et al. J Clin Oncol 2020 Feb 11

A new guideline standardizes best diagnostic practices.

Primary CNS Lymphoma: Treatments and Outcomes in Modern Clinical Practice

Roy E. Strowd, MD reviewing Houillier C et al. Neurology 2020 Jan 6

Older patients represent a large majority of newly diagnosed cases and have high risk for early death.

Implications of Cardiovascular Disease for Prostate Cancer Patients Receiving Androgen-Signaling Inhibitors

Robert Dreicer, MD, MS, MACP, FASCO reviewing Lu-Yao G et al. Eur Urol 2020 Feb

Early mortality was elevated in men with preexisting cardiovascular disease after receiving abiraterone acetate or enzalutamide therapy.

Recurrence of Venous Thromboembolism in the Context of Metabolic Syndrome

Brady L. Stein, MD, MHS reviewing Stewart LK and Kline JA. Blood Adv 2020 Jan 14

VTE recurrence increased with the number of metabolic syndrome components.

Colorectal Cancer in Patients with Ulcerative Colitis

Sunanda V. Kane, MD, MSPH reviewing Olén O et al. Lancet 2020 Jan 11

Risks for CRC incidence and death are higher in UC patients than in population-based controls but may be on the decline.

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