Advanced NSCLC

Pembrolizumab increases historic survival rate

Leading Opinions Digital, 03.06.2019

Five-year data from the phase Ib KEYNOTE-001 clinical trial show that immunotherapy with Pembrolizumab is extending overall survival in people with advanced non-small cell lung cancer expressing PD-L1 of equal or greater than 50%. Pembrolizumab quadrupled pre-immunotherapy era 5-year survival rates for patients when used as initial therapy (23.2% vs. 5.5 %).

KEYNOTE-001 clinical trial shows that pembrolizumab was safe and effective and substantially increased overall survival for advanced non-small cell lung cancer (aNSCLC). Specifically, 23.2% of people who had not previously been treated with chemotherapy and 15.5% of previously-treated patients were alive after five years, with the greatest benefit observed in patients with higher PD-L1 expression. This represents a marked improvement over 5-year survival rates from the pre-immunotherapy era, which averaged 5.5% for aNSCLC. This is the longest follow-up study to date of people with aNSCLC treated with pembrolizumab, according to the researchers.

“The uniformly negative outlook that has been associated with a diagnosis of advanced non-small cell lung cancer is certainly no longer appropriate,” said lead study author Edward B. Garon, MD, MS, Associate Professor of Medicine at UCLA, Los Angeles, CA. “The fact that we have patients on this trial that are still alive after 7 years is quite remarkable. We also have evidence that most patients who are doing well after 2 years on pembrolizumab live for 5 years or more.”

About the Study

In 2011, when KEYNOTE-001 began enrollment, immunotherapy treatments were not widely available, so most participants had previously been treated with systemic medicines, or targeted therapies. There were 550 people with aNSCLC in the trial, including 101 patients who had not previously received any treatment and 449 patients who had received prior treatment. All patients received 2mg/kg of their body weight of pembrolizumab every 3 weeks or 10mg/kg every two or three weeks. In recent years, however, the protocol was changed to a single dose of 200mg regardless of body weight every 3 weeks, the typical regimen in clinical practice.

Key Findings

Patients were followed for a median of 60.6 months, or about 5 years. At that point, 18% of enrollees (100 participants) were still alive. Of those who had not received prior treatment, 23% were still alive after 5 years compared with 15.5% of those previously treated.

Researchers observed that higher levels of PD-L1 expression predicted longest survival. Specifically:

  • In previously untreated people, 29.6% with PD-L1 expression of 50% or more were alive after 5 years compared with 15.7% with expression levels below 50%.
  • In people who had been previously treated, 25% who had PD-L1 expression levels of 50% or more were alive after 5 years compared with 12.6% with expression levels between 1 to 49%. Only 3.5% of people with expression levels below 1% were alive after 5 years.

Among people receiving pembrolizumab after undergoing previous treatment, 42% had responses that lasted for a median of 16.8 months. For those who received pembrolizumab as initial therapy, 23% had responses that lasted a median of 38.9 months.

Immune-related toxic side effects occurred in 17% of enrollees. The most common side effect was hypothyroidism, where the immune system attacks the body’s thyroid glands. The most serious side effect seen was pneumonitis, an inflation of lung tissue, but that was not very common.

Next Steps

Dr. Garon noted that the researchers will try refining their understanding of which patients received the most benefit from pembrolizumab as well as identifying impediments that prevent the immune system from destroying tumors so that these mechanisms could also be combatted. The investigators hope to explore possible combination therapies of pembrolizumab with conventional or other immunotherapies.